Knee Pain Shoulder Pain in Kingston WA

If you are interested in learning about alternative care practices for knee pain and shoulder pain in Kingston WA read this article below.

New Solutions For Knee Pain and Shoulder Pain In Kingston WA

What Is Platelet-rich Plasma (PRP)?

Blood contains platelets, which contain hundreds of proteins called growth factors that are important for the healing of injuries. Growth factors, stored within platelet α-granules, include platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), platelet-derived angiogenic factor (PDAF), and transforming growth factor beta (TGF-β). Growth factors are involved in key stages of wound healing and regenerative processes including chemotaxis, proliferation, differentiation, and angiogenesis. In addition to growth factors (GFs), platelets release numerous other substances including fibronectin, vitronectin, and sphingosine 1-phosphate which are important in wound healing. PRP is obtained by centrifuging blood and extracting the portion of plasma that has a high concentration of platelets, and hence a high concentration of growth factors and other beneficial components.

How Does PRP Work?

Laboratory studies have shown that the increased concentration of growth factors in PRP can speed up the healing process, decrease joint inflammation, and support the regeneration of damaged cartilage in joints. A recent study suggested that PRP modulates the regeneration of damaged joint cartilage by stimulation of mesenchymal stem cell migration, proliferation, and differentiation. Joint injections with PRP have been used in the treatment of knee pain and shoulder pain.

References:

• Hsu WK, Mishra A, Rodeo SR, Fu F, Terry MA, Randelli P, Canale ST, Kelly FB. Platelet-rich plasma in orthopaedic applications: evidence-based recommendations for treatment. Journal of the American Academy Orthopedic Surgery. Dec 2013, 21(12): 739-48.
• van Buul GM, Koevoet WL, Kops N, Bos PK, Verhaar JA, Weinans H, Bernsen MR, van Osch GJ. Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes. American Journal of Sports Medicine. Nov 2011. 39(11): 2362-70.
• Sakata R, Reddi AH. Platelet-Rich Plasma Modulates Actions on Articular Cartilage Lubrication and Regeneration. Tissue Engineering Part B Rev. 2016 Apr 25.